Spravato Success Rate: Exploring Its Effectiveness
Depression is a challenging condition that affects millions of people worldwide. For those who have tried multiple treatments without success, a new option called Spravato® offers hope. In the sections to follow, we'll explore what Spravato is, how effective it is in treating depression, and what you should know if you're considering this treatment.
What is Spravato?
Spravato is an esketamine nasal spray medication approved by the FDA to treat severe forms of depression. It's used specifically for:
- Treatment-Resistant Depression (TRD): This is when standard antidepressants haven't worked well enough. TRD is typically defined as depression that hasn't improved after trying at least two different antidepressant medications at adequate doses and durations. For people with TRD, finding an effective treatment can be particularly challenging and frustrating.
- Major Depressive Disorder (MDD) with Suicidal Thoughts: Spravato can help quickly reduce suicidal thoughts in people with severe depression. This rapid action is essential for individuals in crisis, as traditional antidepressants often take weeks to show effects. Spravato's ability to quickly address suicidal thoughts provides a critical window for other therapeutic interventions to take effect.
How Does Spravato Work?
Spravato represents a breakthrough in depression treatment, operating in a unique way compared to conventional antidepressants. As a nasal spray, it interacts with the brain's glutamate system, a key player in mood regulation. Specifically, Spravato targets a receptor in the brain called N-methyl-D-aspartate (NMDA).
By influencing glutamate activity, Spravato can help promote neuroplasticity, allowing the growth and reconfiguration of neuron pathways. This process strengthens neural connections and communication in the brain, which may lead to improvements in depressive symptoms. This swift action sets it apart from traditional antidepressants, which typically require several weeks to produce noticeable effects.
The ability of Spravato to work quickly is particularly valuable for individuals struggling with severe depression, offering the potential for relief in a matter of hours or days rather than weeks. This rapid onset of action can be crucial for patients who have not responded well to other treatments and are in urgent need of symptom relief.
To learn more about how Spravato works, click here.
Who Can Use Spravato?
Spravato isn't for everyone with depression. It's typically used for adults who:
- Have tried at least two different antidepressants without enough improvement
- Are currently taking an antidepressant
- Don't have certain health conditions that might make Spravato unsafe for them
Regarding health conditions, there are several specific contraindications to be aware of:
- Medical conditions:
- Any history of aneurysm
- Any history of intracranial bleeding
- Psychiatric conditions:
- Presence of psychotic symptoms (such as hallucinations or delusions)
- Substance use-related issues:
- Active substance use disorder or addiction that is not in remission or under control
It's crucial to note that this list is not exhaustive, and there may be other factors that could affect your eligibility for Spravato treatment. A doctor or psychiatrist will need to carefully evaluate your specific situation, including your full medical history and current health status, to determine whether Spravato is a safe and appropriate option for you.
The Effectiveness and Success Rate of Spravato
One of the most promising aspects of Spravato is its effectiveness in treating hard-to-treat depression. Let's take a deeper look at what we know about its success rate based on real-world studies and clinical experiences.
Spravato Success Rate
Studies and real-world use have consistently shown that Spravato has a high success rate, especially considering it's used for people who haven't responded well to other treatments.
For example, one comprehensive study found that 88% of patients showed "much improved" or "very much improved" status after just 0-3 months of Spravato treatment. This is a remarkable rate of improvement, particularly for individuals who have struggled with depression for a long time.
Even more encouraging is that these positive results tend to persist. The same study found that even after two years of treatment, 63% of patients continued to show significant improvement. This suggests that Spravato doesn't just offer a temporary fix but may provide lasting relief for many people.
Other research on patients with treatment-resistant depression analyzed real-world data from 163 adult patients with treatment-resistant depression who received Spravato between March 2019 and June 2022. The study found that after 3-6 months of Spravato treatment, the percentage of patients with severe depression decreased dramatically. At the start of the study, over half of the patients had severe depression. By the end, this number had dropped to about one-fifth. This shows how Spravato can help even those with the most challenging cases of depression.
It's important to note that "success" in treating depression often means significant reductions in symptoms, not necessarily a complete elimination of all symptoms. For many people living with severe depression, this level of improvement can be life-changing.
Quick Relief
One of the most exciting things about Spravato is how fast it can work. Most antidepressants take weeks or even months to start making you feel better. But with Spravato, many people start feeling improvements within hours or days of their first dose.
This quick action is backed up by solid research. Scientists studied Spravato in a large group of people with severe depression, including some who were having thoughts of suicide. Many of these people had tried other antidepressants before without much success.
Here's what they found:
- Some people started feeling better in as little as 4 hours after taking Spravato.
- By 24 hours, there was a clear difference between people who got Spravato and those who didn't. The Spravato group was feeling noticeably better.
- These improvements lasted for several weeks (Fu et al., 2020; Ionescu et al., 2020).
This fast action can be a real lifesaver, especially for people who are really struggling. When you're battling severe depression, every day counts. Waiting weeks for a medication to kick in can feel like forever.
It's worth remembering that everyone's experience with Spravato can be different. Some people might feel better right away, while for others, it might take a little longer. But compared to traditional antidepressants, Spravato generally starts working much faster. This quick relief is one of the reasons why Spravato has given new hope to many people with hard-to-treat depression. It's opening up new possibilities for treatment, especially for those who need help urgently.
Remember, though, that Spravato is usually just one part of a larger treatment plan. Your doctor might also recommend other medications or therapies to work alongside Spravato for the best long-term results.
The Treatment Process
Getting Spravato treatment is a bit different from taking a typical antidepressant. Here's what you can expect:
- You'll go to a certified healthcare facility to receive the treatment.
- A healthcare provider will show you how to use Spravato nasal spray.
- After taking Spravato, you'll need to stay at the facility for about two hours so the staff can monitor you for any side effects.
- You'll need someone to drive you home after each treatment, as you might feel dizzy or sleepy.
For the first month, you'll typically receive treatments twice a week. Then, depending on your progress, you might go once a week or once every two weeks.
Side Effects and Safety
Like all medications, Spravato can have side effects. The most common side effects include:
- Feeling disconnected from yourself (dissociation)
- Dizziness
- Nausea
- Sleepiness
These side effects usually don't last long and often go away within a couple of hours after treatment. That's why you're monitored at the healthcare facility after each dose.
It's important to note that Spravato is generally considered safe when used as directed under medical supervision. The monitoring process helps ensure that any potential issues are caught and addressed quickly.
Is Spravato Covered by Insurance?
Good news for many people considering Spravato: it's often covered by insurance, including many major health plans and Medicare. However, coverage can vary, so it's important to check with your insurance provider. Many treatment centers, like Stella, have staff who can help you figure out your coverage and any out-of-pocket costs.
Comparing Spravato to Ketamine
While Spravato (esketamine) and ketamine are related compounds, there are some important differences to understand:
- Form and Administration: Spravato is a nasal spray, making it easier to administer than ketamine, which is typically given as an IV infusion. This means Spravato treatments can be quicker and less invasive.
- FDA Approval: Spravato is FDA-approved specifically for treatment-resistant depression and major depressive disorder with suicidal thoughts. Ketamine's use for depression, while promising, is considered "off-label" as it's not FDA-approved for this purpose.
- Insurance Coverage: Because Spravato is FDA-approved for depression, it's more likely to be covered by insurance than ketamine infusions.
- Administration and Effectiveness: Spravato is a nasal spray, offering convenient administration, while IV ketamine provides higher bioavailability, potentially leading to faster onset and maximum effectiveness.
- Monitoring Requirements: Spravato must be administered in a certified healthcare setting with monitoring for at least two hours. Ketamine infusion protocols can vary but often require similar monitoring.
- Frequency of Treatment: Initial Spravato treatment is typically twice a week, then decreasing over time. Ketamine infusion schedules can vary but are often similar.
Both Spravato and ketamine have shown promise in rapidly reducing depressive symptoms, especially in cases where other treatments haven't worked. The choice between the two often depends on factors like availability, insurance coverage, and individual patient characteristics. Your healthcare provider can help determine which option might be best for you based on your specific situation.
Should You Take Spravato?
While Spravato has shown promise in treating severe depression, it's not suitable for everyone. Several factors determine whether Spravato is an appropriate treatment option:
- Your depression history, including previous treatments tried
- Current health status and any existing medical conditions
- Potential contraindications that may make Spravato unsafe for you
- Your overall treatment goals and lifestyle considerations
It's crucial to consult with a qualified healthcare provider to determine if Spravato is right for you. They will:
- Examine your symptoms thoroughly
- Review your medical and social history
- Discuss various treatment options, including Spravato
- Explain potential benefits and risks
- Help you understand what to expect from the treatment process
Remember, Spravato is most effective as part of a comprehensive treatment plan, which may include other therapies and lifestyle changes. Your healthcare provider can help create a personalized approach that best addresses your specific needs and circumstances.
About Stella
Stella stands at the cutting edge of mental health care, offering groundbreaking treatments for those struggling with depression, anxiety, and PTSD. We specialize in advanced therapies like Spravato (esketamine) and IV ketamine infusions, complemented by our compassionate, individualized approach to patient care.
Our mission goes beyond simply managing symptoms; we strive to address the underlying causes of mental health challenges. With a network of over 20 locations across the United States, we're making these innovative treatments more accessible to those who haven't found relief through conventional methods.
At Stella, we believe in the power of responsible innovation. Our team of skilled professionals is dedicated to providing trauma-informed care, always prioritizing patient safety while striving for optimal outcomes. We understand that each person's journey to mental wellness is unique, which is why we tailor our treatments to meet individual needs.
If you're exploring Spravato as a potential treatment option, we invite you to connect with us. Our experienced healthcare providers are here to evaluate your specific situation and determine whether this cutting-edge therapy aligns with your needs. We're committed to supporting you every step of the way, leveraging the most advanced and effective treatments available in mental health care.
Choosing Stella means partnering with a team dedicated to your well-being. We believe that with the right care and guidance, treatments like Spravato can be more than just a medication—they can be a transformative step towards reclaiming your life and finding renewed hope. Let us walk alongside you on your path to healing and improved mental health.
Frequently Asked Questions (FAQs)
What is the Success Rate of Esketamine Nasal Spray?
The success rate of esketamine nasal spray, marketed under the brand name Spravato for treatment-resistant depression, has been found to be promising in clinical trials. Studies have shown that it can significantly reduce symptoms of depression within 24 hours for some patients, a rapid response compared to traditional antidepressants. However, the success rate can vary; one comprehensive study found that 88% of patients showed "much improved" or "very much improved" status after just 0-3 months of Spravato treatment.
How Long Does It Take to See Results with Spravato?
The onset of results from Spravato (esketamine) nasal spray, used in combination with an oral antidepressant for treatment-resistant depression, can vary between individuals. According to clinical studies and patient reports, some individuals may begin to notice an improvement in their symptoms within the first 24 hours after treatment, with significant improvements more commonly reported after 2 to 4 weeks of regular use. It's essential for patients to closely monitor their progress with their healthcare provider throughout the treatment course, as responses to the medication can differ.
How Well Does Spravato Work?
Spravato (esketamine) nasal spray, approved for treatment-resistant depression, has shown varying degrees of effectiveness in clinical trials. Spravato can reduce depressive symptoms for some patients who have not responded to other treatments, with effects sometimes noticed within 24 hours. However, results can differ from person to person, and while some patients experience significant improvements, others may find it less effective or encounter side effects that limit its utility.
Resources:
Fu, D.J., Ionescu, D., Li, X., et al., 2020. Esketamine nasal spray for rapid reduction of major depressive disorder symptoms in patients who have active suicidal ideation with intent: double-blind, randomized study (ASPIRE I). J. Clin. Psych. 81 (3), 19m13191. https://doi.org/10.4088/JCP.19m13191
Marci C.D., Karkare S., Jha M.K., et al. Change in depressive symptoms following esketamine initiation among patients with treatment-resistant depression in a realworld setting. Poster presented at: Neuroscience Education Institute (NEI) Congress; November 9-10, 2023; Colorado Springs, CO.
Price, M. Z., & Price, R. L. (2024). Benefits and risks of esketamine nasal spray continuation in treatment-resistant depression. Biomarkers in Neuropsychiatry, 11.link